Harmful History of Neuroleptics-antipsychotics

Preclinical Use 1883 Phenothiazines are developed as synthetic dyes. 1934 USDA develop phenothiazines as insecticides 1949 Phenothiazines shown to hinder rope-climbing in rats. 1950 Rhone Poulenc synthesizes chlorpromazine, a phenothiazine, for use as an anaesthetic. Clinical History 1954 Chlorpromazine marketed in the US as Thorazine, found to induce symptoms of Parkinson’s disease. 1955 Chlorpromazine said … Continue reading Harmful History of Neuroleptics-antipsychotics