As even psychosis has no pathology, and, there is no evidence, that any mental disorder is caused by a chemical imbalance in our brains , what effect do drugs have ?
What permanent damage, do they cause to our brains and bodies ?
How will the Mental Task force recommendations for even more use of anti psychotics and antidepressants, really affect our health and well being ?
And, why, is our government recommending the use of anti psychotics, in light of the scientific evidence of their effect on the brain and body, side effects, and complete lack of any long term benefit ?
Neuroleptics- Anti psychotics
Risperidol, Thorazine, Haldol, and other first, and second generation anti psychotics, powerfully block dopamine pathways in the brain, and reduce a person’s capacity, to respond emotionally to the world, and also make it harder to physically move around it.
On a pathological level, neuroleptics, change the brain’s chemistry, and shrink its volume.
The brain compensates, for the drug induced dopamine block, by producing an increased density, in its dopamine receptors.
Studies have shown, this pathological change, increases a person’s biological vulnerability to psychosis, as schizophrenics treated with neuroleptics, have more severe psychotic symptoms, and relapses, when the drug is withdrawn, than, do those, who have never been treated with anti psychotics.
Philip Seeman published a paper recently, showing both second, and first generation atypical anti psychotics, induce this ‘dopamine super sensitivity’.
And Martin Harrow’s long-term study, showed patients who stopped taking medications, had markedly better outcomes .
He also reported, that medicated patients, were much more likely, to be psychotic on long-term medication, than those taken off early, and concluded, drug-induced dopamine super sensitivity, was likely, to be the reason for the remarkable difference in outcomes.
This super sensitivity, also stops the actual sedative effect of the anti psychotics over time.
So neuroleptics, change the brain chemistry, appearing to actually create psychotic episodes, in those like the autistic and learning disabled.
This suggests, the chemical imbalance theory, that, increased dopamine, causes psychosis, is wrong.
As once a sensitivity is induced, by anti psychotics, the neurotransmitters, desperate for normal levels of dopamine, change their pathology and become over sensitive, and a first psychotic episode, and/or increased episodes result.
Therefore, treatment for schizophrenia, appears, to be based on a false premise, created by the pharma industry, out of its apparent strong sedative effects, as it, historically was used as a tranquiliser.
But it adjusts the brains chemistry to require the lost dopamine, by becoming super sensitive to dopamine detection, and, it is this change, resultant upon a deficiency of dopamine, that causes psychosis.
This surely, suggests, the brain needs, the very dopamine, being blocked to function normally.
Little is known of autism or the effects of reduction in dopamine specific to the autistic here is a study on the increased rates of use in autistic children
How does it feel to be medicated ?
Some have described the effect as like a stroke, others a heavy blanket.
Most, cannot describe how they feel, as they are autistic/ learning disabled, institutionalised, and in any event ignored.
They are turned into zombies by powerful neurological chemical suppression.
As far back as 1972, researchers concluded neuroleptics ‘impaired learning’.
In 2005, a large MRI imaging study by Lieberman, showed statistically, significant shrinkage of the brain’s grey matter, in those treated with haloperidol or olanzapine, after only 12 weeks.
Yet school children, are drugged if autistic/ADHD for years.
These researchers, found, in institutions they sat ‘staring vacantly at television’, and in the community lived in ‘virtual solitude’, socially disengaged and unmotivated.
A study by psychiatrist David Healy, of 20 hospital staff, given 5mg droperidol (a haloperidol type),and then required to perform various psychological tests.
Revealed they all felt heavily sedated, and found, physical and mental activity, required a much greater effort.
One said even obtaining a sandwich from a machine, was just too complicated.
They felt disengaged from events around them, demotivated., restless, anxious, and irritated, some so distressed they felt suicidal.
My 9 year old daughter,on Risperidol in her fruit shots, as treatment for her aggression in fact caused by an undetected poo impaction, cried almost permanently, but, as an autistic, could not describe her misery.
Some also reported, an inability to make judgments, about the effects of the drug, as they found it difficult to identify and describe them, whilst under its influence, so side effects could not be properly ascertained.
Do the benefits outweigh the risks and side effects ?
By the end of the 1970s, the National Institute for Mental Health and leading authority in schizophrenia research William Carpenter, expressed concern, that anti psychotics, might have the perverse effect, over the long-term, of making patients, more biologically vulnerable to psychosis, than they would be, in the normal course of the illness.
This concern was based on an old study by Samuel Bockoven and three new long-term studies, funded by the NIMH.
Additionally, there were growing concerns about the frequency with which, medicated patients were developing tardive dyskinesia.
This led Jonathan Cole, the then head of the NIMH’s Psychopharmacology Service Centre, to write;
“Maintenance Antipsychotic Therapy: Is the Cure Worse than the Disease?”
So after 25 years of studying anti psychotics, researchers came to a terrifying conclusion:
These drugs might in fact, worsen the very symptoms, they were designed to treat, and had devastating side effects.
In the 1990’s the pharmaceutical industry , dealt with this bad PR, by marketing a new range of second generation atypicals, which they purported to have better long-term outcomes.
But, there is no scientific evidence that they do, in fact, they appear worse.
And, the first generation ones, particularly Risperidol, continue to be extensively used.
MRI studies by Gur and Andreasen, show both types of atypicals, caused changes in brain volumes, that were associated with a worsening of positive symptoms, negative symptoms, and functional impairment.
And, recent evidence shows, that anti psychotics shrinking of the brain, has grown even more robust in both new and old atypicals
And as mentioned earlier, the dopamine sensitivity, which appears to cause psychosis, is also induced by the new second generation atypicals.
The World Health Organization, in two cross-cultural studies, reported that schizophrenia patients in three developing countries had markedly better outcomes than in the U.S. and other developed countries, and that in those poor countries, only a small percentage of patients—16%—were regularly maintained on the drugs.
See also the millions paid out for the damage and death caused by anti psychotics in the USA.
We also have to consider the physical side effects, of this powerful neurological suppression, particularly over years of medication.
Here is a Forum of people permanently damaged
Remember, anti psychotics are only licenced in the UK for psychosis, and short term use for severe behavioural problems.
Despite this, they are prescribed ‘off label’ for bi polar, autism, irritability, self harm and behaviour problems,despite the fact, they can cause permanent psychosis, fits, diabetes and tardive dyskinesia, respiratory and heart conditions.
And, appear to have no measurable benefits.
And worse still, are being promoted by our government’s Mental Health Taskforce.
One report from Public Health England estimates around 35,000 people a year are being prescribed antipsychotics and/or antidepressants – often more than one medicine in the same class – without a clear clinical justification, and for a long time without adequate review.